Paving the Way for Breakthroughs in Oral Cancer Research

In the relentless pursuit of advancing our understanding and treatment of Oral cancer, Oracle Cancer Trust played a pivotal role in funding a groundbreaking research project led by Leah Ambler, a PhD student, that has contributed to two major publications that promise to reshape our approach to identifying metastatic cells in human oral cancer tissue.

The first of these groundbreaking research outputs is a paper published in eLife titled “Identification of Metastatic Cells in Human Oral Cancer Tissue.” The study delves deep into the intricate mechanisms underlying the metastasis of oral cancer cells, shedding light on the factors that contribute to the spread of this aggressive disease.

Link to the paper: Identification of Metastatic Cells in Human Oral Cancer Tissue

In addition to the academic publication, the research received recognition in the form of a digest from the journal, available here: eLife Digest. The digest provides a concise overview of the research, making it accessible to a broader audience and emphasizing its significance in the field of cancer research.

The second is a pre-print publication presenting a cutting-edge approach. The research utilizes a microfluidic model of metastasis to unravel the intricate interactions between cancer stem cells and the vasculature in oral cancer. This pre-print represents a leap forward in understanding the complexities of oral cancer metastasis, laying the groundwork for future advancements in therapeutic strategies.

Link to the pre-print: Microfluidic Model of Metastasis in Oral Cancer

In addition to contributing to these studies, Leah has built on these approaches and used our new understanding of the metastatic mechanisms of oral cancer to develop a prognostic signature for oral cancer spread. This is now being trialled in a larger retrospective group of patients which, if initial promising results are confirmed, could pave the way for a clinical test to tailor surgical decision making for oral cancer patients.

Oracle Cancer Trust’s commitment to advancing Head and Neck cancer research is exemplified through the recent successes in Leah’s groundbreaking studies and marks a step forward in the RACE to overcome the Head and Neck cancer crisis.

Follow us

Quick Links

Become an Oracle Friend

Up and coming events

Contact us

Get in touch

Call 020 3875 8991

Email info@oraclecancertrust.org

Registered-logos-grey

Oracle Cancer Trust is a registered charity in England and Wales (1142037), and in Scotland (SC052790).

Registered as a company limited by guarantee in England and Wales (7125497). Registered address: 80 Coombe Road, New Malden KT3 4QS.

Charity Administrator Job – We’re recruiting

We are looking for a dedicated Administrator to join our team.

Oracle´s Golf Day 2025 – Sonning GC, Reading

Oracle´s annual golf day is on 13th June 2025 at Sonning Golf Club, Reading.

Oracle´s annual Oncology meeting

meeting to discuss cutting edge advancements in the treatment of head and neck cancer

Magical Christmas Concert at the enchanting Lumley Castle

Oracle proudly presents a Magical Christmas Concert at the enchanting Lumley Castle on 30th November 2024

Cancer Treatment Wait Times risking lives

Patients face long delays, only 50% seen within the NHS target of 62 days.

Jamie Theakston announces Laryngeal cancer diagnosis

Jamie has had a lesion removed from his vocal chords (Larynx)

Make Sense Campaign 2024

Oracle Head & Neck Cancer UK Supports Make Sense Campaign 2024 Raising Awareness for Head and Neck Cancer We are proud to support the Make Sense Campaign (16th – 21st…

News coverage heralds the start of annual HPV vaccinations

Another busy week for Oracle HNCUK promoting the start of the annual autumn HPV vaccination programme for year 8 children in UK high schools.

Annual Winter Glory Concert, Nov 21st 2024

Join us for an evening of uplifting classical music and a chance to reconnect with fellow supporters.

Mouth Cancer Awareness – NHS England and Asda Team Up

New look mouthwash and toothpaste products encourage shoppers to be body aware and contact their GP or dental practice.

Cancer Support Group 6 Year Anniversary

“We could never have imagined just how amazing it would be and just how supportive you would all be to each other”

World Head & Neck Cancer Awareness day 2024

World Head & Neck Cancer Awareness day 2024 presentation at Merck & Co to promote #HeadNeckCheck

Respiratory-Swallow Training in Head and Neck Cancer

New training, which aims to change the breathing-swallowing pattern of patients with swallowing difficulties, has been developed in America.

EasyJet Boarding Pass – Check in and check out information on head & neck cancers.

An estimated 40,000 passengers are being told to ‘Silence the threat. Give it the check’ in the our latest campaign.

Help Beat Head and Neck Cancer