Paving the Way for Breakthroughs in Oral Cancer Research

PHD researcher Leah Ambler in the lab

In the relentless pursuit of advancing our understanding and treatment of Oral cancer, Oracle Cancer Trust played a pivotal role in funding a groundbreaking research project led by Leah Ambler, a PhD student, that has contributed to two major publications that promise to reshape our approach to identifying metastatic cells in human oral cancer tissue.

The first of these groundbreaking research outputs is a paper published in eLife titled “Identification of Metastatic Cells in Human Oral Cancer Tissue.” The study delves deep into the intricate mechanisms underlying the metastasis of oral cancer cells, shedding light on the factors that contribute to the spread of this aggressive disease.

Link to the paper: Identification of Metastatic Cells in Human Oral Cancer Tissue

In addition to the academic publication, the research received recognition in the form of a digest from the journal, available here: eLife Digest. The digest provides a concise overview of the research, making it accessible to a broader audience and emphasizing its significance in the field of cancer research.

The second is a pre-print publication presenting a cutting-edge approach. The research utilizes a microfluidic model of metastasis to unravel the intricate interactions between cancer stem cells and the vasculature in oral cancer. This pre-print represents a leap forward in understanding the complexities of oral cancer metastasis, laying the groundwork for future advancements in therapeutic strategies.

Link to the pre-print: Microfluidic Model of Metastasis in Oral Cancer

In addition to contributing to these studies, Leah has built on these approaches and used our new understanding of the metastatic mechanisms of oral cancer to develop a prognostic signature for oral cancer spread. This is now being trialled in a larger retrospective group of patients which, if initial promising results are confirmed, could pave the way for a clinical test to tailor surgical decision making for oral cancer patients.

Oracle Cancer Trust’s commitment to advancing Head and Neck cancer research is exemplified through the recent successes in Leah’s groundbreaking studies and marks a step forward in the RACE to overcome the Head and Neck cancer crisis.

Follow us

Quick Links

Become an Oracle Friend

Up and coming events

Contact us

Get in touch

Call 020 3875 8991



Oracle Cancer Trust is a registered charity in England and Wales (1142037), and in Scotland (SC052790).

Registered as a company limited by guarantee in England and Wales (7125497). Registered address: 80 Coombe Road, New Malden KT3 4QS.

Brave Hearts Take the Plunge

On a crisp Boxing Day morning in Redcar, courageous sisters Caroline and Ann, decided to make a splash in the icy waters of the North Sea to raise crucial funds…

Ed Vanson and Guy Randall strike a chord for good with #Tedstock

In the heart of our community, there are individuals whose passion and dedication shine like a beacon, illuminating the way for positive change. Ed Vanson, a local radio DJ, and…

Peter’s Passion: A Golf Tournament that Tees Up Charity Support

In the world of charitable endeavours, the spirit of giving often takes shape in diverse and creative forms. One such example of this philanthropic spirit is Peter Papanastasiou, an individual…

Walking the North Downs Way in Memory of Dad

On Saturday 9th July 2023, Peter’s friends and family walked 16.5 miles of the North Downs Way from Wye and Folkestone, an area Peter and his wife Isabelle called home…

192 Mile coast-to-coast walk to mark 5 years cancer free

5 years after receiving treatment for a nasty Head and Neck cancer, Caroline Outterside, considers herself as one of the lucky ones and wants to give back. Accompanied by her…

Young Tongues Fund Launch

Oracle Cancer Trust has partnered up with peer-to-peer support group the Young Tongues to set up the Young Tongues Fund; funding patient support activities led by the Young Tongues, awareness…

Inaugural Peter Rhys-Evans Memorial Trophy won at Oracle Cancer Trust Golf Day

Oracle Cancer Trust’s annual Golf Day at the exclusive Cowdray Estate raises £9,043.26, whilst crowing first Peter Rhys-Evans Memorial champions.  On a fabulously sunny morning in May, at the breathtakingly…

Tubby FC hold charity match in memory of George Johnston

On the 19th May Tubby FC took on Whittington Cat FC at St Benedicts RUFC in Whitehaven in support of Oracle Cancer Trust and in memory of George Johnston and…

Lauren comes to the rescue and completes London Marathon 2023 for Oracle

Oracle Cancer Trust thrilled as Lauren Graham bravely steps up to run the London Marathon with only weeks’ notice following fellow runners’ injury. With only weeks’ to go until the…

9th Annual Charity Spring Ball in aid of Oracle Cancer Trust raises over 3k

Long term Oracle Cancer Trust supporter Angela Bryant, who was diagnosed with tonsil cancer in 2010, hosts annual charity spring ball for the 9th time and raises £3,603 for the…

#TeamOracle completes Chiltern Challenge

Group of Oracle Cancer Trust Fundraisers complete 20 mile Chiltern Challenge on East Monday. The day started with dark skies and torrential rain, but that wasn’t going to stop our…